Juq-139 Jun 2026

Imagine a world where technology seamlessly integrates with our daily lives, enhancing experiences and solving problems with unprecedented efficiency. This vision is rapidly becoming a reality, with JUQ-139 at the forefront.

Recombinant human PI3K‑α (p110α/p85α) and isoforms β, δ, γ were purchased from SignalChem. Enzyme activity was measured using a homogeneous time‑resolved fluorescence (HTRF) assay (Kinase‑Glo, Promega). IC₅₀ values were derived from four‑parameter logistic fits (GraphPad Prism 9). JUQ-139

Our group previously identified a 1,3‑benzothiazole‑based series (compound series ) that displayed modest PI3K‑α inhibition (K i ≈ 120 nM) but suffered from poor metabolic stability (Patel et al., 2021). In an effort to improve potency, selectivity, and pharmacokinetic (PK) properties, we pursued a hybrid design merging the benzothiazole core with a pyrazolo[1,5‑a]pyridine fragment, a privileged motif known to enhance kinase binding through a hinge‑region hydrogen bond (Wang et al., 2018). The resulting molecule, JUQ‑139 , incorporates a sulfonamide tether bearing a para‑fluorophenyl‑propyl side chain to improve oral absorption and metabolic stability. Imagine a world where technology seamlessly integrates with

In the realm of modern technology and innovation, certain designations and codenames often spark curiosity and intrigue. One such enigmatic term that has been making waves in various circles is "JUQ-139." This cryptic label has piqued the interest of tech enthusiasts, researchers, and the general public alike, leaving many to wonder about its significance and the story behind it. In an effort to improve potency, selectivity, and

A. R. Patel (arpatel@ipsny.edu)

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