Open Systems Pharmacology

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Reliable, powerful and easy-to-use modeling & simulation tools for pharmaceutical and other life-sciences applications. Qualified and accepted by the scientific community including academia, regulatory agencies and industry. Available free to everyone.

Essentials

Download OSP Suite

Explore the full functionality of the OSP suite. PBPK, PBPK/PD, QSP – the OSP Suite gives you the flexibility to build it all without having to start from scratch.

Forum

Have your questions answered or provide answers to others. The Forum is a great way to stay up-to-date on the community buzz around OSP.

Documentation

Need to find out how to use a feature? Looking to understand the inner workings of the model? Here you’ll find the extensive OSP manual and qualification documents.

News & Release

Save the Date: OSP Community Conference 2026

In Beerse, Antwerp September 24th and 25th

Open Systems Pharmacology Suite - Version 12 Update 2

We are pleased to announce the new release of the OSP Suite Version 12 Update 2 which is now available for download.

WORKSHOP AT ACOP COLORADO.

Join ESQlabs at the ACoP Conference in Colorado Building Scalable PBPK-QSP Models - Modularization in MoBi for OSP Suite V12.

Ready to take the plunge? Download

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The current 2026 season has been dominated by highly anticipated sequels that have consistently topped community ratings on platforms like MyAnimeList. Frieren: Beyond Journey's End

Navigating thousands of titles requires a robust user interface. Effective platforms utilize advanced filtering systems, allowing users to sort content by:

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When users search for the "best" content on the platform, they are typically looking for titles filtered by specific community metrics:

For those seeking a perfectly constructed narrative with universal appeal, Fullmetal Alchemist: Brotherhood (anime) and its source manga by Hiromu Arakawa represent the gold standard. The story follows brothers Edward and Alphonse Elric, who use alchemy in a failed attempt to resurrect their dead mother, costing Ed an arm and a leg, and Al his entire body. Their quest to restore themselves becomes a sprawling conspiracy thriller involving military corruption, forbidden knowledge, and the nature of sacrifice. What makes Brotherhood exceptional is its structural integrity. Every character, from the main villains to a rural housewife, serves a purpose. The anime adaptation famously follows the manga’s complete story without the filler detours of its 2003 predecessor, resulting in a tight, 64-episode arc that pays off every single setup. Its theme—that nothing is gained without equal cost, and that blind faith in systems or power is dangerous—is mature without being cynical. For a viewer who wants a complete, emotionally devastating yet ultimately hopeful story with phenomenal action and world-building, Brotherhood is the definitive recommendation. The current 2026 season has been dominated by

Shojo, a genre aimed at a female audience, typically features romance, relationships, and character development. Here are some popular shojo anime and manga recommendations:

Start with Spy x Family or Demon Slayer → then Attack on Titan or Frieren . For a manga reader new to anime: Try Chainsaw Man (anime) or Vinland Saga (anime). For a veteran seeking depth: Monster (anime) or Goodnight Punpun (manga only). A rugged Viking stared back

| Genre | Manga Title | Why Manga > Anime | |-------|-------------|--------------------| | | Homunculus | No anime; body horror & identity exploration – manga art essential. | | Romance | Kaguya-sama: Love is War | Anime is great, but manga continues further with deeper character arcs. | | Horror | Junji Ito Collection (e.g., Uzumaki ) | Anime adaptations fail to capture Ito’s detailed linework. | | Sports | Haikyuu!! | Anime is excellent, but manga’s final arc (nationals) not fully adapted well. | | Historical / Art | Vagabond | No complete anime; ink-painting art style is a must-see in print. | | Slice-of-Life | Yokohama Kaidashi Kikō | Tranquil, atmospheric – never fully animated. |

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Publications & Models

Models

Glucose Insulin Model

Scientifically exciting for diabetes researchers. Technically exciting for everyone with PBPK models of glucose, insulin, and glucagon coupled through non-mechanistic PD as well as systems pharmacology PD models.

Publications

Journal Publications

Growing list of scientific journal publications that relates to OSP or describes work with PK-Sim® or MoBi®. Add your own contributions and label them or others appropriately to further grow and structure this database.

Take a look at all our models Browse

Management Team

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